Program ERGECD-ETCASS 2021


29TH ERGECD – 10th ITCASS – Programme
February 3-5, 2021 at Ecole Normale Supérieure, 15 parvis René Descartes, Lyon, France

Program Itcass & ERGECD in .pdf


Wednesday, 3rd February 2021 : ITCASS-ERGECD


10th ITCASS Meeting
9.15 – 9.30 Opening of 10TH ITCASS Meeting

Round 1 – Title session
Chairs:
9.30 – 10.30 Presentations
1. Key Lecture, Marc Pallardy – Paris
2. Understanding human exposure and health hazard of micro- and nanoplastic contaminants in our environment, Raymond Pieters – Utrecht
3. Innate-like B-1 lymphocytes collaborate with macrophages in pulmonary particle-induced responses and granuloma formation, Léa Hiéronimus – Brussels
4. Upcoming Title, Ambra Madallon – Milan
10.30 – 11.00 Questions to speakers
11.00 – 11.30 Break

Round 2 – Title session
Chairs:
11.30 – 12.30 Presentations
1. Upcoming Title, Erica Buoso – Pavia
2. Characterization of chemical-specific CD4+ T cells in human blood, Caterina Curato – Berlin
3. Molecular mechanisms of T-cell mediated adverse drug reactions targeting the skin and blood, Monday Ogese – Liverpool
4. Immune responses in reconstructed human skin on chip upon exposure to sensitizers, Jasper Koning – Amsterdam
12.30 – 13.00 Questions to speakers
13.00 – 13.15 Closure of 10th ITCASS Meeting

29th ERGECD Meeting
14.00 – 14.05 Opening of the 29TH ERGECD

Round 1 – Protein reactivity and skin sensitization assessment
Chairs: Andreas Natsch – Vernier / Marc Pallardy – Paris
14.05 – 15.05 Presentations
1. Detection of free radicals from skin sensitizers: EPR-spin trapping an essential tool, Yannick Port-Lougarre – Strasbourg
2. Charaterization of hapten-protein adducts, Lorena Ndreu – Stockholm
3. Linalool hydroperoxides: new chemical inputs on skin sensitization radical mechanisms, Elena Gimenez-Arnau – Strasbourg
4. Probing the skin with ToF-SIMS: Do metal allergens change lipid composition?, Niamh O’Boyle – Dublin
5. Skin sensitizers in clothes – occurrence, skin uptake and assessment exposure, Josefine Carlsson – Stockholm
15.05 – 15.35 Questions to speakers
15.35 – 16.00 Break
16.00 – 17.00 Presentations
6. Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin, Sander Spiekstra – Amsterdam
7. Assessment of fragrance ingredients for skin sensitization potential using U-SENS™, Isabelle Lee – Newark
8. RHE-LC, reconstructed epidermis including Langerhans Cells, a useful tool for skin immunity studies and evaluation, Jean-Marc Ovigne – Lyon
9. Future perspective of immunocompetent skin and lymph node on chip, Sue Gibbs – Amsterdam
17.00 – 17.30 Questions to speakers


Thursday, 4th February 2021


Round 2 – Activation of the innate and adaptive immune system
Chairs: Stefan Martin – Freiburg / Marc Vocanson – Lyon
9.00 – 9.30 Guest lecture “Cutaneous immune responses to external stimuli”, Kenji Kabashima – Kyoto

9.30 – 10.30 Presentations
1. Molecular adaptation of a monocyte cell line to hapten exposure, Johanna Morot – Lyon
2. Understanding the chemical allergen potency: the role of miRNAs in keratinocytes, Martina Iulini – Milan
3. Understanding the chemical allergen potency: the role of miRNAs in dendritic cells, Valentina Galbiati – Milan
4. Dual role of CinA on IL-1b regulation through Nrf2 pathway activation in keratinocytes, Romain Vallion – Châtenay-Malabry
5. Opposite responses to contact allergens in mice with two common skin protein mutations, Mia Hamilton Jee – Copenhagen
10.30 – 11.00 Questions to speakers
11.00 – 11.30 Break
11.30 – 12.30 Presentations
6. Feeding of fat-enriched diet causes the loss of resistance to contact hypersensitivity, Anne-Catherine Rülh-Muth – Freiburg im Breisgau
7. Role of skin microbiome in immunosuppression to contact allergens, VijayKumar Patra – Lyon
8. Distinct features of metal-specific human CD4+ T cell receptors, Katherina Siewert – Berlin
9. How T-cells recognize chemicals?, Marc Pallardy – Châtenay-Malabry
10. Characterisation of T-cell involvement in DILI to a range of implicated therapeutics, Paul Thomson – Liverpool
12.30 – 13.00 Questions to speakers
13.00 – 14.00 Break
14.00 – 14.45 Presentations
11. Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic contact dermatitis, Anne Sophie Gadsboll – Copenhagen
12. CD8+ epidermal-resident memory T cells recruit neutrophils that are essential for allergeninduced flare-ups in contact dermatitis, Anders Boutrup Funch – Copenhagen
13. Impact of corticosteroids on the biology of skin resident memory T cells and the
recurrence of eczema, Emi Ono – Lyon
14.45 – 15.00 Questions to speakers

Round 3 – Skin sensitization assessment & risk assessment
Chairs: Elena Gimenez-Arnau – Strasbourg / Valentina Galbiati – Milan / Petra Kern – Strombeek – Bever
15.00 – 16.00 Presentations
1. The predictivity of the kinetic DPRA (kDPRA) for sensitizer potency assessment, Andreas Natsch – Vernier
2. The kinetic Direct Peptide Reactivity Assay (kDPRA): Intra- and inter-laboratory reproducibility in a seven-laboratory ring trial, Susanne Kolle – Ludwigshafen
3. TBD: Next Generation risk assessment: a case study, Nathalie Alépée – Aulnay-Sous-Bois
4. Development and application of a Next Generation Risk Assessment Framework (NGRA) for the Evaluation of Skin Sensitisation of Cosmetic Ingredients, Fanny Boislève – Neuilly-Sur-Seine
16.00 – 16.30 Questions to speakers
16.30 – 17.00 Break
17.00 – 17.45 Presentations
5. Weight of Evidence Approach for Skin Sensitization Potency Categorization of Fragrance Materials, Mihwa Na – Woodcliff Lake
6. Update on the Bayesian Net Defined Approach, Petra Kern – Strombeek-Bever
7. How to assure consumer safety in skin sensitization without animal testing: demonstration through a case study with resorcinol, Fleur Tourneix – Aulnay-sous-Bois
17.45 – 18.00 Questions to speakers


Friday, 5th February 2021



Round 3 – Human allergy/immunology
Chairs: Saadia Kerdine-Romer – Paris / Ana-Maria Gimenez-Arnau – Barcelona / Jean-François Nicolas – Lyon
9.00 – 9.30 Guest lecture “Upcoming title”, Thomas Rustemeyer – Amsterdam
9.30 – 10.30 Presentations
1. The allergic signature of Amerchol™ L-101-induced contact dermatitis, Marine-Alexia Lefèvre – Lyon
2. Compendium of practices on career guidance for youth with atopic dermatitis, Marie-Noëlle Crépy – Paris
3. Dermatitis venenata: the state of contact dermatitis one hundred years ago, David Gawkrodger – Sheffield
4. Unusual contact dermatitis to a transcutaneous electrical nerve stimulation device, Audrey Nosbaum – Lyon
10.30 – 11.00 Questions to speakers
11.00 – 11.30 Break
11.30 – 12.30 Presentations
5. Prevention of photosensitivity with action spectrum adjusted protection for erythropoietic protoporphyria, Takashi Teramura – Lyon
6. Clinical prognosis of vaccine-related itching nodules – a 20 year follow-up, Anette Gente Lidholm – Goteborg
7. Skin sensitivity to capsaicin, stress and burn out among patients with building related
symptoms, Bo Glas – Umea
8. Fluorescent visualization of melanosome distribution in human skin tissue, Chikako Yoshikawa – Lyon
12.30 – 13.00 Questions to speakers
13.00 – 13.15 Closure of the 29th ERGECD


24/08/2020